PROCEEDINGS BOOK
WELCOME
Dear Colleagues and Friends,
As Presidents of the 5th ASPIC International Congress, and on behalf of the ASPIC Direction and the Organizing and Scientific Committees, it is with great enthusiasm that we invite you to attend this congress, which will be held on June 30th and July 1st, at the IPO-Porto Auditorium, Porto, Portugal.
The ASPIC Congress is coming back to IPO-Porto, after a big success in 2018. In that meeting, we were thrilled to have 425 participants that created a warm environment to discuss the latest discoveries in cancer research. In 2022, we expect to hold another rewarding meeting, which will also represent an excellent opportunity to physically meet each other again and to learn, face-to-face, about new developments in cancer research, share results and discoveries through oral presentations and through a big and participative Poster Session.
You are invited to take an active part in this conference, which we believe will be an outstanding scientific event. We hope that you will take the opportunity to benefit from the exciting scientific programme and from new contacts and collaborations. During the meeting, there will be great opportunities for young scientists to meet the experts in the field, and we aim to create an open and engaging environment for discussion.
We look forward to welcoming you at the fantastic city of Porto.
Luís Costa and Rui Henrique
(Presidents of the 5th ASPIC International Congress)
Scientific & Organizing Committee
Joana Paredes
Júlio Oliveira
Jorge Lima
Bruno Costa
Cláudia Faria
Ana Preto
Carmen Jerónimo
Luisa Melo
Scientific Evaluation Committee
Chair: Bruno Costa-Silva
Ana Luísa Correia
Ana Sofia Ribeiro
Célia Gomes
Cláudia Faria
Fátima Baltazar
Peter Jordan
Raquel Almeida
Key Dates
Early registration deadline: 09/05/2022
Abstract submission deadline: 09/05/2022
Scientific Programme
Europe/Lisbon ( GMT)
30th June, 2022
9:30h – 10:00h
Opening Session
Joana Paredes (ASPIC/i3S), Luís Costa (CHULN/IMM) and Rui Henrique (IPO-Porto/ICBAS)
10:00h – 11:00h
ASPIC Lecture
BRCA2-P study: National characterization of the Portuguese founder mutation of the BRCA2 gene
Fátima Vaz (IPO-Lisbon)
11:00h – 11:30h
COFFEE BREAK
Symposium I – Cancer Genomics and Epigenomics
Chair: Bruno Costa (ICVS/ U.Minho) and Cláudia Faria (CHULN/IMM)
11:30h – 12:00h
Epigenetic contributions to Leukemia
Christoph Plass (DKFZ German Cancer Research Center)
12:00h – 12:15h
Selected Oral Communication:
T-cell receptor and Ccr7 chemokine receptor involvement in leukemic T cell dissemination
Ivette Pacheco-Leyva (i3S)
12:15h – 12:45h
The histone methyltransferase DOT1L in cytotoxic T cells: targeting epigenetic regulation at the core
Fred van Leeuwen (NKI – Netherlands Cancer Institute)
12:45h – 13.00h
Selected Oral Communication:
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells
Sandra Tavares (University Medical Center Utrecht and i3S)
13:00h – 14:00h
LUNCH BREAK
14:00h – 16:00h
Poster Session
16:00h – 16:30h
COFFEE BREAK
Symposium II – Porto.Comprehensive Cancer Centre
Chair : Carmen Jerónimo (IPO-Porto/ICBAS) and José Carlos Machado (FMUP/i3S)
16:30h – 17:00h
Epigenetic modulators in solid tumors: drug development guided by clinical and traslational research
Irene Braña (Vall d’Hebron University Hospital)
17:00h – 17:15h
Selected Oral Communication:
3D heterotypic culture systems to study immune modulation and antibody response in HER2+ breast cancer microenvironment
Sofia Batalha (iBET/ITQB NOVA)
17:15h – 17:45h
Turning Sweet on Immuno-Oncology: glycans as key immune-checkpoints in cancer with clinical implications
Salomé Pinho (i3S/FMUP/ICBAS)
17:45h – 18.00h
Selected Oral Communication:
Patient-derived organoids recapitulate the gastric cancer glycosylation profile: a new model to identify novel cancer target therapies
Filipe Pinto (i3S)
18:00h – 19:00h
ASPIC General Assembly and Elections
20:00h
Congress Dinner
1st July, 2022
Plenary Lectures
Chair : Leonor David (Ipatimup/FMUP) and João Barata (IMM/FMUL)
9:30h – 10:15h
EACR Lecture
The potential of liquid biopsy in the management of cancer patients
Evi Lianidou (University of Athens)
10:15h – 11:00h
ASEICA Lecture
Breast cancer metastasis cell fate mapping
Roger Gomis (IRB Barcelona)
11:00h – 11:30h
COFFEE BREAK
Symposium III – Tumour Microenvironment
Chair : Joana Paredes (ASPIC/i3S) and Ana Preto (CBMA, U.Minho)
11:30h – 12:00h
The microbiota-immunity axis in gastrointestinal cancers
Amedeo Amedei (University of Florence)
12:00h – 12.15h
Selected Oral Communication:
Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis
Rita Carvalho (i3S/ICBAS)
12:15h – 12:45h
Neutrophil extracellular traps in the tumour microenvironment: exploring a possible mechanism of acquired immune escape
Carlos Eduardo de Andrea (Universidade de Navarra) – Sponsored by ILC
12:45h – 13:00h
Selected Oral Communication:
Cadherin-3 is a novel oncogenic biomarker with prognostic value in glioblastoma
Eduarda P. Martins (ICVS/3B’s)
13:00h – 14:00h
LUNCH BREAK
14:00h – 15:00h
Poster Session
Symposium IV – Translational Cancer Research
Chair : Jorge Lima (i3S/Ipatimup) and Júlio Oliveira (IPO-Porto)
15:00h – 15:30h
ITCC-P4: a sustainable platform of molecularly well-characterized PDX models of pediatric cancers for high-throughput drug testing in vivo
Marcel Kool (Hopp Children’s Cancer Center Heidelberg & Princess Maxima, Center Pediatric Oncology Utrecht)
15:30h – 15.45h
Selected Oral Communication:
Genetic engineering of Mesenchymal Stromal Cells to express anti-cancer proteins
Marília Silva (IBB/IST)
15:45h – 16:15h
Universal fast testing of patients with infiltrating lung adenocarcinomas: from UTOPIA to reality
Fernando López-Ríos (12 de Octubre University Hospital Spain) – Sponsored by Thermo Fisher Scientific
16:15h – 16:30h
Selected Oral Communication:
Chitosan/y-PGA nanoparticles-based immunotherapy as adjuvant to IFN-y in breast cancer
Flávia Castro (i3S)
16:30h – 17:00h
COFFEE BREAK
17:00h – 17:30h
AWARDS & CLOSING SESSION
Joana Paredes (ASPIC/i3S)